{"id":43,"date":"2019-09-06T19:29:46","date_gmt":"2019-09-06T19:29:46","guid":{"rendered":"http:\/\/web.devl.snet.biobio.tamu.edu\/saclab\/?page_id=43"},"modified":"2025-09-15T19:42:00","modified_gmt":"2025-09-15T19:42:00","slug":"publications","status":"publish","type":"page","link":"https:\/\/saclab.biobio.tamu.edu\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column]\n\t\t\t<!-- START Publications REVOLUTION SLIDER 6.7.35 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"barbers_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"barbers\" style=\"\" data-version=\"6.7.35\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-275\" data-title=\"Slide\" data-anim=\"ms:1000;r:0;\" data-in=\"o:-0.5;sx:1.6;sy:1.6;e:power0.inOut;\" data-out=\"o:0;sx:0.6;sy:0.6;\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"\/\/saclab.biobio.tamu.edu\/wp-content\/plugins\/revslider\/sr6\/assets\/assets\/dummy.png\" alt=\"Slide\" title=\"Publications\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/saclab.biobio.tamu.edu\/wp-content\/plugins\/revslider\/sr6\/assets\/assets\/transparent.png\" data-bg=\"c:#ffffff;\" data-parallax=\"4\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-183-slide-275-layer-2\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,r,r,r;xo:725px,0,0,0;yo:5px,4px,0,0;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:530px,400px,282px,140px;h:13px;\"\n\t\t\t\t\t\t\t\tdata-vbility=\"t,t,f,f\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:100%;o:1;tp:600;\"\n\t\t\t\t\t\t\t\tdata-frame_0_mask=\"u:t;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"tp:600;st:1000;sp:1500;sR:1000;\"\n\t\t\t\t\t\t\t\tdata-frame_1_mask=\"u:t;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;tp:600;st:w;sR:6500;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:10;background-color:#ffe11b;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-183-slide-275-layer-14\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#000000\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;\"\n\t\t\t\t\t\t\t\tdata-text=\"s:18,18,18,15;l:22;ls:6px;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:100%;o:1;tp:600;\"\n\t\t\t\t\t\t\t\tdata-frame_0_mask=\"u:t;x:-100%;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"tp:600;e:power4.inOut;st:300;sp:2000;sR:300;\"\n\t\t\t\t\t\t\t\tdata-frame_1_mask=\"u:t;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;tp:600;st:w;sR:6700;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:6;font-family:'Barlow Condensed';text-transform:uppercase;\"\n\t\t\t\t\t\t\t>OUR PUBLICATIONS \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-183-slide-275-layer-15\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"yo:5px,4px,0,0;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:510px,393px,275px,140px;h:13px,13px,15px,13px;\"\n\t\t\t\t\t\t\t\tdata-vbility=\"t,t,f,f\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:100%;o:1;tp:600;\"\n\t\t\t\t\t\t\t\tdata-frame_0_mask=\"u:t;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"x:0,0,0px,0px;y:0,0,0px,0px;tp:600;st:1000;sp:1500;sR:1000;\"\n\t\t\t\t\t\t\t\tdata-frame_1_mask=\"u:t;x:0,0,0px,0px;y:0,0,0px,0px;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;tp:600;st:w;sR:6500;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:9;background-color:#ffe11b;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script>\n\t\t\t\t\tsetREVStartSize({c: 'barbers',rl:[1240,1366,778,480],el:[80,80,960,26],gw:[1240,1024,778,480],gh:[80,80,80,80],type:'standard',justify:'',layout:'fullwidth',mh:\"0\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"barbers\"]!==undefined) {window.RS_MODULES.modules[\"barbers\"].once = false;window.revapi183 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n<style type=\"text\/css\" >#b_op6197cq6gb2cgwwafmc a{color:#000000; background:; margin-top:0px; margin-bottom:0px;  margin-left:0px; margin-right:0px; font-weight:700; border-radius:0px;}#b_op6197cq6gb2cgwwafmc a:hover{color:#ffffff ; background:#500000 ;}<\/style><div class=\"ta_left tf_btn_pos\" id=\"b_op6197cq6gb2cgwwafmc\" ><a class=\"rd_normal_bt medium_rd_bt bt_icon_right  rda_fadeIn \" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=sacchettini+j&amp;sort=date\" target=\"yes\"   ><span>For all publications, continue to PubMed page.<\/span><i class=\"st-arrow-right\" ><\/i><\/a><\/div><style type=\"text\/css\" >#b_op6197cq6gb2cgwwafmc i {color:#500000;}#b_op6197cq6gb2cgwwafmc a:hover i{color:#ffffff;}<\/style><style type='text\/css'> @font-face{font-family: 'st'; src:url('https:\/\/saclab.biobio.tamu.edu\/wp-content\/themes\/thefox\/includes\/4k-icons\/icons\/4k-icons-pack04\/icons\/fonts\/st.eot'); src:url('https:\/\/saclab.biobio.tamu.edu\/wp-content\/themes\/thefox\/includes\/4k-icons\/icons\/4k-icons-pack04\/icons\/fonts\/st.eot?#iefix') format('embedded-opentype'), url('https:\/\/saclab.biobio.tamu.edu\/wp-content\/themes\/thefox\/includes\/4k-icons\/icons\/4k-icons-pack04\/icons\/fonts\/st.woff') format('woff'), url('https:\/\/saclab.biobio.tamu.edu\/wp-content\/themes\/thefox\/includes\/4k-icons\/icons\/4k-icons-pack04\/icons\/fonts\/st.ttf') format('truetype'), url('https:\/\/saclab.biobio.tamu.edu\/wp-content\/themes\/thefox\/includes\/4k-icons\/icons\/4k-icons-pack04\/icons\/fonts\/st.svg#oi') format('svg'); 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color:#000000;}#tle_lnhj0jtz2zkipr5w4nge span.timeline_event_date_ctn:nth-of-type(even) .timeline_event_date,#tle_lnhj0jtz2zkipr5w4nge span.timeline_event_date_ctn:nth-of-type(even) h2{background:#ffffff; color:#000000;}#tle_lnhj0jtz2zkipr5w4nge div.timeline_event:nth-of-type(even):after {color:#500000;}#tle_lnhj0jtz2zkipr5w4nge div.timeline_event:nth-of-type(odd):before {color:#FCB614;}#tle_lnhj0jtz2zkipr5w4nge {margin-top:0px; margin-bottom:0px; }<\/style>\n<!-- Timeline Event --><div class=\"timeline_event_ctn  clearfix\" id=\"tle_lnhj0jtz2zkipr5w4nge\"><div class=\"v_line\"><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/12\/nature_logo-250x250.jpg\" width=\"250\" height=\"250\" alt=\"nature_logo\" title=\"nature_logo\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>1.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09286-3\" target=\"_blank\" rel=\"noopener\">SuFEx-based antitubercular compound irreversibly inhibits Pks13<\/a><\/strong><\/h5>\n<h6 class=\"p1\"><span style=\"color: #800000;\"><strong><span class=\"s1\"><span class=\"s2\">Inna V. Krieger<\/span><\/span><\/strong>,\u00a0<span class=\"s3\">Paridhi Sukheja<\/span>,\u00a0<span class=\"s3\">Baiyuan Yang<\/span>,\u00a0<strong><span class=\"s3\">Su Tang<\/span><\/strong>,\u00a0<strong><span class=\"s3\">Daniel Selle<\/span>,<\/strong>\u00a0<span class=\"s3\">Ashley Woods<\/span>,\u00a0<span class=\"s3\">Curtis Engelhart<\/span>,\u00a0<span class=\"s3\">Pradeep Kumar<\/span>,\u00a0<span class=\"s3\">Michael B. Harbut<\/span>,\u00a0<span class=\"s3\">Dongdong Liu<\/span>,\u00a0<span class=\"s3\">Brendan Tsuda<\/span>,\u00a0<span class=\"s3\">Bo Qin<\/span>,\u00a0<span class=\"s3\">Grant A. L. Bare<\/span>,\u00a0<span class=\"s3\">Gencheng Li<\/span>,\u00a0<span class=\"s3\">Victor Chi<\/span>,\u00a0<span class=\"s3\">Julian Gambacurta<\/span>,\u00a0<span class=\"s3\">Janine Hvizdos<\/span>,\u00a0<span class=\"s3\">Matthew Reagan<\/span>,\u00a0<span class=\"s3\">Isabelle L. Jones<\/span>,\u00a0<span class=\"s3\">Lisa M. Massoudi<\/span>,\u00a0<span class=\"s3\">Lisa K. Woolhiser<\/span>,\u00a0<span class=\"s3\">Alessandro Cascioferro<\/span>,\u00a0<span class=\"s3\">Erica Kundrick<\/span>,\u00a0<span class=\"s3\">Parul Singh<\/span>,\u00a0<span class=\"s3\">William Reiley<\/span>,\u00a0<span class=\"s3\">Thomas R. Ioerger<\/span>,\u00a0<span class=\"s3\">Dilipkumar Reddy Kandula<\/span>,\u00a0<span class=\"s3\">Jacob W. McCabe<\/span>,\u00a0<span class=\"s3\">Taijie Guo<\/span>,\u00a0<span class=\"s3\">David Alland<\/span>,\u00a0<span class=\"s3\">Helena I. Boshoff<\/span>,\u00a0<span class=\"s3\">Dirk Schnappinger<\/span>,\u00a0<span class=\"s3\">Gregory T. Robertson<\/span>,\u00a0<span class=\"s3\">Khisi Mdluli<\/span>,\u00a0<span class=\"s3\">Kyoung-Jin Lee<\/span>,\u00a0<span class=\"s3\">Jiajia Dong<\/span>,\u00a0<span class=\"s3\">Shuangwei Li<\/span>,\u00a0<span class=\"s3\">Peter G. Schultz<\/span>,\u00a0<span class=\"s3\">Sean B. Joseph<\/span>,\u00a0<span class=\"s3\">Melissa S. Love<\/span>,\u00a0<span class=\"s3\">K. Barry Sharpless<\/span>,\u00a0<span class=\"s3\">H. Michael Petrassi<\/span>,\u00a0<span class=\"s3\">Arnab K. Chatterjee<\/span>,\u00a0<strong><span class=\"s3\">James C. Sacchettini<\/span>\u00a0<\/strong>&amp;\u00a0<span class=\"s3\">Case W. McNamara<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">30 July 2025<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/10\/acs-publications-vector-logo-small-250x250.png\" width=\"250\" height=\"250\" alt=\"https:\/\/pubs.acs.org\/\" title=\"https:\/\/pubs.acs.org\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>2.<\/h2><p><\/p>\n<h5 class=\"article_header-title\" tabindex=\"0\"><strong><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jmedchem.5c00856\" target=\"_blank\" rel=\"noopener\"><span class=\"hlFld-Title\">Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase<\/span><\/a><\/strong><\/h5>\n<h6><span style=\"color: #800000;\">Amrita Singh,Logan T. Zwerneman, Kyle Planck, Takushi Kaneko, Andrew J. Perkowski, Christine M. Suh, Alexander Alex, James Bean, Kristin Burns-Huang, David Zhang, Helena I. M. Boshoff, Christine Roubert, <strong>Inna Krieger<\/strong>, Mark Gardner, Bastien Cautain, Christopher B. Cooper, Zaid Tanvir,<strong> James Sacchettini<\/strong>, Ben S. Gold, Kyu Y. Rhee, Nader Fotouhi, Carl F. Nathan, Jeffrey Aub\u00e9<\/span><\/h6>\n<h6><span style=\"color: #800000;\">1 July 2025<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2024\/11\/Dcellpress.gif\" width=\"80\" height=\"80\" alt=\"Dcellpress\" title=\"Dcellpress\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>3.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124724012804?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><strong>An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo<\/strong><\/a><\/h5>\n<h6 class=\"article_header-title\"><span style=\"color: #800000;\"><strong>Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z,<\/strong> Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, <strong>Acharya A,<\/strong> Shin J, <strong>Rathi MM,<\/strong> Wolff KC, Riva L, Bakowski MA, McNamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, <strong>Sacchettini JC.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\">5 November 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-25-at-3.21.47\u202fPM-1-250x250.png\" width=\"250\" height=\"250\" alt=\"Screenshot 2024-07-25 at 3.21.47\u202fPM\" title=\"Screenshot 2024-07-25 at 3.21.47\u202fPM\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>4.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><strong><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.8242\" target=\"_blank\" rel=\"noopener\">Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions<\/a><\/span><\/strong><\/h5>\n<h6 class=\"article_header-title\"><span style=\"color: #800000;\">Henriques-Santos BM, <strong>Baker D, Zhou N, Snavely T, Sacchettini JC*,<\/strong> Pietrantonio PV.\u00a0<\/span><\/h6>\n<h6><span style=\"color: #800000;\">20 June 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2023\/12\/logo-american-society-for-microbiology.png\" width=\"160\" height=\"160\" alt=\"logo-american-society-for-microbiology\" title=\"logo-american-society-for-microbiology\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>5.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00112-24\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #000000;\"><strong>Identification of a copper-responsive small molecule inhibitor of uropathogenic\u00a0<i>Escherichia coli<\/i><\/strong><\/span><\/a><\/h5>\n<h6><span style=\"color: #800000;\">Hanson BS, Hailemariam A, Yang Y, Mohamed F, Donati GL, <strong>Baker D, Sacchettini J*<\/strong>, Cai JJ, Subashchandrabose S.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">10 June 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>6.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-48448-1\" target=\"_blank\" rel=\"noopener\"><strong>Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin<\/strong><\/a><\/h5>\n<h6 class=\"article_header-title\"><span style=\"color: #800000;\">Qu D, Ge P, Botella L, Park SW, Lee HN, Thornton N, Bean JM, <strong>Krieger IV, Sacchettini JC*<\/strong>, Ehrt S, Aldrich CC, Schnappinger D.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">16 May 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>7.<\/h2><p><\/p>\n<h5 class=\"article_header-title\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.3c00592\" target=\"_blank\" rel=\"noopener\"><span class=\"hlFld-Title\">Inhibitors of the Thioesterase Activity of\u00a0<i>Mycobacterium tuberculosis<\/i>\u00a0Pks13 Discovered Using DNA-Encoded Chemical Library Screening<\/span><\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><strong>Inna V. Krieger<\/strong>, Subbarao Yalamanchili, Paige Dickson, Curtis A. Engelhart, Matthew D Zimmerman, <strong>Jeremy Wood<\/strong>, <strong>Ethan Clary<\/strong>, <strong>Jasmine Nguyen<\/strong>, Natalie Thornton, Paolo A. Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Gui\u00e9, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D. Hupp, Rachael Jetson, Takashi Satoh, John T. S. Yeoman, Ying Zhang, Veronique Dartois, Dirk Schnappinger, Anthony D. Keefe*, and <strong>James C. Sacchettini*<\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\">5 April 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2024\/03\/download.png\" width=\"225\" height=\"225\" alt=\"download\" title=\"download\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>8.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciadv.adj6406?af=R&amp;mi=0&amp;target=default\" target=\"_blank\" rel=\"noopener\">Redirecting raltitrexed from cancer cell thymidylate synthase to\u00a0<i>Mycobacterium tuberculosis<\/i>\u00a0phosphopantetheinyl transferase<\/a><\/strong><\/span><\/h5>\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<h6 class=\"authors-list\"><span style=\"color: #800000;\"><span class=\"authors-list-item \">Amrita Singh<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Samantha Ottavi<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Inna Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kyle Planck<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Andrew Perkowski<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Takushi Kaneko<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Andrew M Davis<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christine Suh<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">David Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Laurent Goullieux<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Alexander Alex<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christine Roubert<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Mark Gardner<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Marian Preston<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dave M Smith<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yan Ling<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Julia Roberts<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Bastien Cautain<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Anna Upton<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christopher B Cooper<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Natalya Serbina<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zaid Tanvir<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>John Mosior<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ouathek Ouerfelli<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Guangli Yang <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ben S Gold<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kyu Y Rhee <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Nader Fotouhi<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jeffrey Aub\u00e9 <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Carl Nathan<\/span><\/span><\/h6>\n<\/div>\n<\/div>\n<h6><span style=\"color: #800000;\">15 March 2024<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2023\/12\/logo-american-society-for-microbiology.png\" width=\"160\" height=\"160\" alt=\"logo-american-society-for-microbiology\" title=\"logo-american-society-for-microbiology\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>9.<\/h2><p><\/p>\n<h5><strong><a href=\"https:\/\/journals.asm.org\/doi\/abs\/10.1128\/jb.00202-23\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #000000;\"><i>Bacillus subtilis<\/i>\u00a0YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization<\/span><\/a><\/strong><\/h5>\n<h6><span style=\"color: #800000;\" role=\"list\"><span role=\"listitem\">Tingfeng Guo<\/span>,\u00a0<span role=\"listitem\">Anthony M.\u00a0Sperber<\/span>,\u00a0<strong><span role=\"listitem\">Inna V.\u00a0Krieger<\/span><\/strong>,\u00a0<span role=\"listitem\">Yi\u00a0Duan<\/span>,\u00a0<span role=\"listitem\">Veronica R.\u00a0Chemelewski<\/span>,\u00a0<strong><span role=\"listitem\">James C.\u00a0Sacchettini<\/span><\/strong>,\u00a0<span role=\"listitem\">Jennifer K.\u00a0Herman<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">4 December 2023<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>10.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsmedchemlett.3c00162\" target=\"_blank\" rel=\"noopener\"><strong><i>Mycobacterium tuberculosis<\/i>\u00a0PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Samantha Ottavi<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kelin Li<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jackson G Cacioppo<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Andrew J Perkowski<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Remya Ramesh,<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \">Ben S Gold<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yan Ling<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Julia Roberts<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Amrita Singh<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">David Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>John Mosior<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Laurent Goullieux<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christine Roubert<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Eric Bacqu\u00e9<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Carl F Nathan<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jeffrey Aub\u00e9<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">26 June 2023<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>11.<\/h2><p><\/p>\n<h5 class=\"article_header-title\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.3c00034\" target=\"_blank\" rel=\"noopener\"><span class=\"hlFld-Title\">DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery<\/span><\/a><\/strong><\/span><\/h5>\n<h6><strong><span style=\"color: #800000;\"><span class=\"hlFld-ContribAuthor\">Siddhant Rath, <\/span><span class=\"hlFld-ContribAuthor\">Saswati Panda, <\/span><span class=\"hlFld-ContribAuthor\">James C. Sacchettini<\/span>, <\/span><\/strong><span style=\"color: #800000;\"><span class=\"hlFld-ContribAuthor\">Steven J. Berthel<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">22 June 2023<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/CellLogo_reasonably_small_400x400-250x250.jpg\" width=\"250\" height=\"250\" alt=\"Cell\" title=\"Cell\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>12.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867423001022?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents<\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Jidong Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christine Lair<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Christine Roubert<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kwame Amaning<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Mar\u00eda Bel\u00e9n Barrio<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yannick Benedetti<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zhicheng Cui<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zhongliang Xing<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Xiaojun Li<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Scott G Franzblau<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Nicolas Baurin<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Florence Bordon-Pallier<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Cathy Cantalloube<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Stephanie Sans<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sandra Silve,<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \">Isabelle Blanc<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Laurent Fraisse<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Alexey Rak<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Lasse B Jenner<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Gulnara Yusupov<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Marat Yusupov<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Junjie Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Takushi Kaneko<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">T J Yang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Nader Fotouhi,<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \">Eric Nuermberger<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sandeep Tyagi<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Fabrice Betoudji<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Anna Upton<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sophie Lagrange<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">2 March 2023<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>13.<\/h2><p><\/p>\n<h5 class=\"article_header-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.2c00392\" target=\"_blank\" rel=\"noopener\"><strong><span class=\"hlFld-Title\">1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB\/BC Complex in\u00a0<i>Mycobacterium tuberculosis<\/i><\/span><\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Singh V, Grzegorzewicz AE, Fienberg S, M\u00fcller R, Khonde LP, Sanz O, Alfonso S, Urones B, Drewes G, Bantscheff M, Ghidelli-Disse S, Ioerger TR, Angala B, Liu J, Lee RE,\u00a0<strong>Sacchettini JC, Krieger IV<\/strong>, Jackson M, Chibale K, Ghorpade SR.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">3 November 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>14.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><strong><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-022-30389-2\" target=\"_blank\" rel=\"noopener\">Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists<\/a><\/span><\/strong><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Sachin S Katti<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Inna V Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jihyae Ann<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jeewoo Lee<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Tatyana I Igumenova<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">16 May 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>15.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-022-29832-1\" target=\"_blank\" rel=\"noopener\"><strong>CinA mediates multidrug tolerance in\u00a0<i>Mycobacterium tuberculosis<\/i><\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Kaj M Kreutzfeldt<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Robert S Jansen<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Travis E Hartman<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Alexandre Gouzy<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ruojun Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Inna V Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Matthew D Zimmerman<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Martin Gengenbacher<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jansy P Sarathy<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Min Xie<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">V\u00e9ronique Dartois<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kyu Y Rhee<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dirk Schnappinger <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sabine Ehrt<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">22 April 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>16.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-28078-1\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"color: #000000;\">Interplay between an ATP-binding cassette F protein and the ribosome from\u00a0<i>Mycobacterium tuberculosis<\/i><\/span><\/strong><\/a><\/h5>\n<h6><span style=\"color: #800000;\">Cui Z, <strong>Li Xiaojun<\/strong>, Shin J, Gamper H, Hou YM, <strong>Sacchettini JC<\/strong>, Zhang J.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">21 January 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>17.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.1c01565\" target=\"_blank\" rel=\"noopener\"><strong>In Vitro and In Vivo Inhibition of the\u00a0<i>Mycobacterium tuberculosis<\/i>\u00a0Phosphopantetheinyl Transferase PptT by Amidinoureas<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Ottavi S, Scarry SM, <strong>Mosior J<\/strong>, Ling Y, Roberts J, <strong>Singh A<\/strong>, Zhang D, Goullieux L, Roubert C, Bacqu\u00e9 E, Lagiakos HR, Vendome J, Moraca F, Li K, Perkowski AJ, Ramesh R, Bowler MM, Tracy W, Feher VA,\u00a0<strong>Sacchettini JC<\/strong>, Gold BS, Nathan CF, Aub\u00e9 J.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">19 January 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>18.<\/h2><p><\/p>\n<h5 class=\"article_header-title\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.1c01586\" target=\"_blank\" rel=\"noopener\"><span class=\"hlFld-Title\">Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target<\/span><\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Wilson C, Ray P, Zuccotto F, Hernandez J, <strong>Aggarwal A<\/strong>, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, <strong>Parai MK<\/strong>, <strong>Acharya A<\/strong>, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Rom\u00e1n EM, Torres-G\u00f3mez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D,\u00a0<strong>Sacchettini JC<\/strong>, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG.<\/span><\/h6>\n<h6><span style=\"color: #800000;\">13 January 2022<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>19.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.1c00627\" target=\"_blank\" rel=\"noopener\"><strong>Second-Shell Amino Acid R266 Helps Determine\u00a0<i>N<\/i>-Succinylamino Acid Racemase Reaction Specificity in Promiscuous\u00a0<i>N<\/i>-Succinylamino Acid Racemase\/\u00a0<i>o<\/i>-Succinylbenzoate Synthase Enzymes<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Dat P Truong<span style=\"font-size: 8.93333px;\">,<\/span><span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Simon Rousseau<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Benjamin W Machala<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jamison P Huddleston<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Mingzhao Zhu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kenneth G Hull<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Daniel Romo<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Frank M Raushel<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Margaret E Glasner<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">30 November 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>20.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c07970\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #000000;\"><strong>Mechanism-Based Inactivation of\u00a0<i>Mycobacterium tuberculosis<\/i>\u00a0Isocitrate Lyase 1 by (2\u00a0<i>R<\/i>,3\u00a0<i>S<\/i>)-2-Hydroxy-3-(nitromethyl)succinic acid<\/strong><\/span><\/a><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Drake M Mellott<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dan Torres<span class=\"comma\">,<strong>\u00a0<\/strong><\/span><\/span><span class=\"authors-list-item \"><strong>Inna V Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Scott A Cameron<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zahra Moghadamchargari<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Arthur Laganowsky<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Thomas D Meek<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Lawrence D Harris<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">27 October 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/12\/nature_logo-250x250.jpg\" width=\"250\" height=\"250\" alt=\"nature_logo\" title=\"nature_logo\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>21.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41378-021-00262-1\" target=\"_blank\" rel=\"noopener\"><strong>Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of\u00a0<i>Mycobacterium smegmatis<\/i><\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Han Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Gloria M Conover<span class=\"comma\">,\u00a0 <\/span><\/span><span class=\"authors-list-item \">Song-I Han<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Arum Han<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">20 May 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/10\/unnamed-250x250.jpg\" width=\"250\" height=\"250\" alt=\"https:\/\/jb.asm.org\/\" title=\"https:\/\/jb.asm.org\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>22.<\/h2><p><\/p>\n<h5 class=\"content-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/journals.asm.org\/doi\/10.1128\/Spectrum.00928-21\" target=\"_blank\" rel=\"noopener\"><strong>Characterization of Phosphopantetheinyl Hydrolase from\u00a0<\/strong><em class=\"genus-species\"><strong>Mycobacterium tuberculosis<\/strong><\/em><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pandey+S&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Shilpika Pandey\">Shilpika Pandey<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Singh+A&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Amrita Singh\">Amrita Singh<\/a><span style=\"font-size: 8.93333px;\">, <\/span><span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yang+G&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Guangli Yang\">Guangli Yang<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=d%27Andrea+FB&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Felipe B d'Andrea\">Felipe B d&#8217;Andrea<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Jiang+X&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Xiuju Jiang\">Xiuju Jiang<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hartman+TE&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Travis E Hartman\">Travis E Hartman<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mosior+JW&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"John W Mosior\"><strong>John W Mosior<\/strong><\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bourland+R&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ronnie Bourland\"><strong>Ronnie Bourland<\/strong><\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Gold+B&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ben Gold\">Ben Gold<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Roberts+J&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Julia Roberts\">Julia Roberts<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Geiger+A&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Annie Geiger\">Annie Geiger<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tang+S&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Su Tang\">Su Tang<\/a><\/strong><span class=\"comma\"><strong>,<\/strong>\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rhee+K&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Kyu Rhee\">Kyu Rhee<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ouerfelli+O&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ouathek Ouerfelli\">Ouathek Ouerfelli<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sacchettini+JC&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"James C Sacchettini\">James C Sacchettini<\/a><\/strong><span class=\"comma\"><strong>,<\/strong>\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nathan+CF&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Carl F Nathan\">Carl F Nathan<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" style=\"color: #800000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Burns-Huang+K&amp;cauthor_id=34550010\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Kristin Burns-Huang\">Kristin Burns-Huang<\/a><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">22 September 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/GQ33i4Hv_400x400-250x250.jpg\" width=\"250\" height=\"250\" alt=\"GQ33i4Hv_400x400\" title=\"GQ33i4Hv_400x400\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>23.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41591-021-01442-2\" target=\"_blank\" rel=\"noopener\"><strong>The Tuberculosis Drug Accelerator at year 10: what have we learned?<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Bree B. Aldridge,\u00a0David Barros-Aguirre,\u00a0Clifton E. Barry III,\u00a0Robert H. Bates,\u00a0Steven J. Berthel,\u00a0Helena I. Boshoff,\u00a0Kelly Chibale,\u00a0Xin-Jie Chu,\u00a0Christopher B. Cooper,\u00a0V\u00e9ronique Dartois,\u00a0Ken Duncan,\u00a0Nader Fotouhi,\u00a0Fabian Gusovsky,\u00a0Philip A. Hipskind,\u00a0Dale J. Kempf,\u00a0Jo\u00ebl Leli\u00e8vre,\u00a0Anne J. Lenaerts,\u00a0Case W. McNamara,\u00a0Valerie Mizrahi,\u00a0Carl Nathan,\u00a0David B. Olsen,\u00a0Tanya Parish,\u00a0H. Michael Petrassi,\u00a0Alexander Pym,\u00a0Kyu Y. Rhee,\u00a0Gregory T. Robertson,\u00a0Jeremy Michael Rock,\u00a0Eric J. Rubin,\u00a0Betsy Russell,\u00a0David G.Russell,\u00a0<strong>James C. Sacchettini<\/strong>,\u00a0Dirk Schnappinger,\u00a0Michael Schrimpf,\u00a0Anna M. Upton,\u00a0Peter Warner,\u00a0Paul Graham Wyatt\u00a0&amp;\u00a0Ying Yuan\u00a0<\/span><\/h6>\n<h6><span style=\"color: #800000;\">05 July 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/97edd8de-c784-4fe2-837d-216cc5b75aaa.png.200x200_q95_detail_letterbox_upscale.png\" width=\"200\" height=\"200\" alt=\"97edd8de-c784-4fe2-837d-216cc5b75aaa.png.200x200_q95_detail_letterbox_upscale\" title=\"97edd8de-c784-4fe2-837d-216cc5b75aaa.png.200x200_q95_detail_letterbox_upscale\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>24.<\/h2><p><\/p>\n<h5 class=\"wi-article-title article-title-main\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/rupress.org\/jem\/article\/218\/7\/e20191957\/212052\/Metabolic-bifunctionality-of-Rv0812-couples-folate\" target=\"_blank\" rel=\"noopener\">Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in\u00a0<em>Mycobacterium tuberculosis<\/em><\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Katherine A Black<span class=\"comma\">,<strong>\u00a0<\/strong><\/span><\/span><span class=\"authors-list-item \"><strong>Lijun Duan<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Lungelo Mandyoli<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Bruna P Selbach<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Weizhen Xu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sabine Ehrt<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kyu Y Rhee<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">05 May 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2021\/07\/ACSPubs-Tagline-CMYK-250x250.png\" width=\"250\" height=\"250\" alt=\"ACSPubs-Tagline-CMYK\" title=\"ACSPubs-Tagline-CMYK\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>25.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.0c00740\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"color: #000000;\">Covalent Inactivation of\u00a0<i>Mycobacterium tuberculosis<\/i>\u00a0Isocitrate Lyase by\u00a0<i>cis<\/i>-2,3-Epoxy-Succinic Acid<\/span><\/strong><\/a><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Truc Viet Pham<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Drake M Mellott, <\/span><span class=\"authors-list-item \">Zahra Moghadamchargari<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kevin Chen, <\/span><span class=\"authors-list-item \"><strong>Inna Krieger<\/strong><span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">Arthur Laganowsky<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Thomas D Meek<\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">10 Mar 2021<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>26.<\/h2><p><\/p>\n<h5 class=\"c-article-title\" data-test=\"article-title\"><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-020-19959-4\" target=\"_blank\" rel=\"noopener\">Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in\u00a0<i>Mycobacterium tuberculosis<\/i><\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Jared S Mackenzie<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dirk A Lamprecht<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Rukaya Asmal<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">John H Adamson<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Khushboo Borah<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dany J V Beste<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Bei Shi Lee<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kevin Pethe<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Simon Rousseau<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Inna Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>James C Sacchettini<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Joel N Glasgow<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Adrie J C Steyn<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">30 Nov 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/elife-logo-250x250.png\" width=\"250\" height=\"250\" alt=\"eLife\" title=\"eLife\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>27.<\/h2><p><\/p>\n<h5 class=\"heading-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/elifesciences.org\/articles\/57081\" target=\"_blank\" rel=\"noopener\"><strong>A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \">Danish Khan<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Dongju Lee<sup class=\"equal-contrib-container\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><strong><span class=\"authors-list-item \">Gulcin Gulten , <\/span><\/strong><span class=\"authors-list-item \"><strong>Anup Aggarwal<\/strong> <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Joshua Wofford<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Inna Krieger<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ashutosh Tripathi <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">John W Patrick<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Debra M Eckert<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Arthur Laganowsky <span class=\"comma\">,<strong>\u00a0<\/strong><\/span><\/span><span class=\"authors-list-item \"><strong>James C. Sacchettini<\/strong> <span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Paul Lindahl<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Vytas A Bankaitis<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">11 Aug 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/07\/sciencedirect-logo-vector-1.png\" width=\"150\" height=\"150\" alt=\"sciencedirect-logo-vector\" title=\"sciencedirect-logo-vector\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>28.<\/h2><p><\/p>\n<h5><strong><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022283620304095?via%3Dihub\" target=\"_blank\" rel=\"noopener\">The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition<\/a><\/span><\/strong><\/h5>\n<h6><span style=\"color: #800000;\"><span class=\"authors-list-item \"><strong>Inna Krieger<\/strong>,<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Vladimir Kuznetsov<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jeng-Yih Chang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Junjie Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Samir Moussa<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ryland Young<span class=\"comma\">,\u00a0<\/span><\/span><strong><span class=\"authors-list-item \">James C Sacchettini<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><\/span><\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\">17 June 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/05\/Science_AAAS-logo-2864F7E76F-seeklogo.com_.gif\" width=\"200\" height=\"200\" alt=\"https:\/\/science.sciencemag.org\" title=\"https:\/\/science.sciencemag.org\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>29.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aaz8899\" target=\"_blank\" rel=\"noopener noreferrer\">Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice<\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><strong>Liam M. Guthrie<\/strong>, Shivatheja Soma, Sai Yuan, <strong>Andres Silva<\/strong>, Mohammad Zulkifli, <strong>Thomas C. Snavely<\/strong>, <strong>Hannah Faith Greene,<\/strong> <strong>Elyssa Nunez<\/strong>, <strong>Brogan Lynch, Courtney De Ville,<\/strong> Vinit Shanbhag, Franklin R. Lopez, <strong>Arjun Acharya<\/strong>, Michael J. Petris, Byung-Eun Kim, Vishal M. Gohil, <strong>James C. Sacchettini<\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\">8 May 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>30.<\/h2><p><\/p>\n<h5 class=\"c-article-title u-h1\" data-test=\"article-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-020-15876-8\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in\u00a0Mycobacterium tuberculosis<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Robert S. Jansen, <strong>Lungelo Mandyoli<\/strong>, <strong>Ryan Hughes<\/strong>, Shoko Wakabayashi, Jessica T. Pinkham, Bruna Selbach, Kristine M. Guinn, Eric J. Rubin, <strong>James C. Sacchettini<\/strong> &amp; Kyu Y. Rhee<\/span><\/h6>\n<h6><span style=\"color: #800000;\">23 April 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/04\/wiley-online-library-250x250.jpg\" width=\"250\" height=\"250\" alt=\"https:\/\/onlinelibrary.wiley.com\/\" title=\"https:\/\/onlinelibrary.wiley.com\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>31.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/pro.3813\" target=\"_blank\" rel=\"noopener noreferrer\">Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.<\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #993300;\"><span style=\"color: #800000;\"><strong>John Mosior, Ronnie Bourland<\/strong>, Shivatheja Soma, Carl Nathan, <strong>James C. Sacchettini<\/strong><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">29 March 2020<\/span><\/h6>\n<h5><\/h5>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/04\/NPG.png\" width=\"150\" height=\"150\" alt=\"https:\/\/www.nature.com\/ja\/\" title=\"https:\/\/www.nature.com\/ja\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>32.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41429-020-0293-6\" target=\"_blank\" rel=\"noopener noreferrer\">Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening.<\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Junichi Taira, Tomohiro Umei, Keitaro Inoue, Mitsuru Kitamura, Francois Berenger,<strong> James C. Sacchettini<\/strong>, Hiroshi Sakamoto &amp; Shunsuke Aoki<\/span><\/h6>\n<h6><span style=\"color: #800000;\">9 March 2020<\/span><\/h6>\n<h5><\/h5>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>33.<\/h2><p><\/p>\n<h5 class=\"content-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-019-14238-3\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>The molecular basis of pyrazinamide activity on\u00a0<em>Mycobacterium tuberculosis PanD<\/em><\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #993300;\"><span style=\"color: #800000;\"><strong>Qingan Sun,\u00a0Xiaojun Li<\/strong>,\u00a0Lisa M. Perez, Wanliang Shi,\u00a0Ying Zhang,\u00a0and\u00a0<strong>James C. Sacchettini<\/strong><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\">17 January 2020<\/span><\/h6>\n<h6><\/h6>\n<p><\/p><\/div><\/div><\/div>\r\n\r\n<!-- Timeline Event END-->\n[\/vc_tab][vc_tab use_icon=&#8221;yes&#8221; title=&#8221;Selected Publications&#8221; tab_id=&#8221;19fe076d-9ffa-4&#8243; icon=&#8221;bk-graduate&#8221;]<style type=\"text\/css\" >#tle_tpjyq9ayyhjljvy2yjxp .v_line{background: #500000; background: -moz-linear-gradient(top, #500000 1%, #FCB614 100%); background: -webkit-gradient(linear, left top, left bottom, color-stop(1%,#500000), color-stop(100%,#FCB614)); background: -webkit-linear-gradient(top, #500000 1%,#FCB614 100%); background: -o-linear-gradient(top, #500000 1%,#FCB614 100%); background: -ms-linear-gradient(top, #500000 1%,#FCB614 100%); background: linear-gradient(to bottom, #500000 1%,#FCB614 100%); filter: progid:DXImageTransform.Microsoft.gradient( startColorstr=\"#500000\", endColorstr=\"#FCB614\",GradientType=0 );}#tle_tpjyq9ayyhjljvy2yjxp .event_img{border-color:#ecf0f1;}#tle_tpjyq9ayyhjljvy2yjxp .event_info h2{color:#000000;}#tle_tpjyq9ayyhjljvy2yjxp .event_info p{color:#000000;}#tle_tpjyq9ayyhjljvy2yjxp span.timeline_event_date_ctn:nth-of-type(odd) .timeline_event_date,#tle_tpjyq9ayyhjljvy2yjxp span.timeline_event_date_ctn:nth-of-type(odd) h2{background:#ffffff; color:#000000;}#tle_tpjyq9ayyhjljvy2yjxp span.timeline_event_date_ctn:nth-of-type(even) .timeline_event_date,#tle_tpjyq9ayyhjljvy2yjxp span.timeline_event_date_ctn:nth-of-type(even) h2{background:#ffffff; color:#000000;}#tle_tpjyq9ayyhjljvy2yjxp div.timeline_event:nth-of-type(even):after {color:#500000;}#tle_tpjyq9ayyhjljvy2yjxp div.timeline_event:nth-of-type(odd):before {color:#FCB614;}#tle_tpjyq9ayyhjljvy2yjxp {margin-top:0px; margin-bottom:0px; }<\/style>\n<!-- Timeline Event --><div class=\"timeline_event_ctn  clearfix\" id=\"tle_tpjyq9ayyhjljvy2yjxp\"><div class=\"v_line\"><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/Science_AAAS-logo-2864F7E76F-seeklogo.com_.gif\" width=\"200\" height=\"200\" alt=\"Science-AAAS\" title=\"Science-AAAS\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>1.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><strong><a style=\"color: #000000;\" href=\"https:\/\/science.sciencemag.org\/content\/368\/6491\/620\" target=\"_blank\" rel=\"noopener noreferrer\">Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice<\/a><\/strong><\/span><\/h5>\n<h6><span style=\"color: #800000;\"><strong>Liam M. Guthrie,<\/strong> Shivatheja Soma, Sai Yuan, <strong>Andres Silva<\/strong>, Mohammad Zulkifli, <strong>Thomas C. Snavely<\/strong>, <strong>Hannah Faith Greene,<\/strong> <strong>Elyssa Nunez<\/strong>, <strong>Brogan Lynch, Courtney De Ville<\/strong>, Vinit Shanbhag, Franklin R. Lopez, <strong>Arjun Acharya<\/strong>, Michael J. Petris, Byung-Eun Kim, Vishal M. Gohil, <strong>James C. Sacchettini<\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Science.<\/strong><\/em> 2020 May 8;368(6491). PMID: 32381719<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2020\/02\/nature-communications-250x250.jpeg\" width=\"250\" height=\"250\" alt=\"https:\/\/www.nature.com\/ncomms\/\" title=\"https:\/\/www.nature.com\/ncomms\/\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>2.<\/h2><p><\/p>\n<h5 class=\"content-title\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.nature.com\/articles\/s41467-019-14238-3\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>The molecular basis of pyrazinamide activity on\u00a0<em>Mycobacterium tuberculosis PanD<\/em><\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #993300;\"><span style=\"color: #800000;\"><strong>Qingan Sun,\u00a0Xiaojun Li,<\/strong>\u00a0Lisa M. Perez, Wanliang Shi,\u00a0Ying Zhang,\u00a0and\u00a0<strong>James C. Sacchettini<\/strong><\/span><\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Nature Communications.<\/strong><\/em> 2020 Jan 17; 339; PMID: 31953389<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/Science_AAAS-logo-2864F7E76F-seeklogo.com_.gif\" width=\"200\" height=\"200\" alt=\"Science-AAAS\" title=\"Science-AAAS\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>3.<\/h2><p><\/p>\n<h5><a href=\"https:\/\/www.science.org\/lookup\/doi\/10.1126\/science.aau8959\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #000000;\"><strong>Opposing reactions in coenzyme A metabolism sensitize\u00a0<em>Mycobacterium tuberculosis<\/em>\u00a0to enzyme inhibition<\/strong><\/span><\/a><\/h5>\n<h6><span style=\"color: #800000;\">Elaine Ballinger, <strong>John Mosior,<\/strong> Travis Hartman, Kristin Burns-Huang, Ben Gold, Roxanne Morris, Laurent Goullieux, Isabelle Blanc, Julien Vaubourgeix, Sophie Lagrange, Laurent Fraisse, St\u00e9phanie Sans, Cedric Couturier, Eric Bacqu\u00e9, Kyu Rhee, Sarah M. Scarry, Jeffrey Aub\u00e9, Guangbin Yang, Ouathek Ouerfelli, Dirk Schnappinger, Thomas R. Ioerger, Curtis A. Engelhart, Jennifer A. McConnell, Kathrine McAulay, Allison Fay, Christine Roubert, <strong>James Sacchettini<\/strong>, Carl Nathan<\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Science.<\/strong><\/em>\u00a02019 Feb 1;363(6426). PMID: 30705156<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInRight\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/elife-logo-250x250.png\" width=\"250\" height=\"250\" alt=\"eLife\" title=\"eLife\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>4.<\/h2><p><\/p>\n<h5><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6333443\/\"><strong><em>\u00a0Mycobacterium tuberculosis<\/em>\u00a0SatS is a chaperone for the SecA2 protein export pathway.<\/strong><\/a><\/span><\/h5>\n<h6><span style=\"color: #800000;\">Miller BK, <strong>Hughes R<\/strong>, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, <strong>Sacchettini JC<\/strong>, Braunstein M. <\/span><\/h6>\n<h6><span style=\"color: #800000;\"><strong><em>Elife.<\/em> <\/strong>2019 Jan 3;8. PMID: 30604681<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/life_sci_alliance-1.png\" width=\"200\" height=\"200\" alt=\"Life-Sci-Alliance\" title=\"Life-Sci-Alliance\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>5.<\/h2><p><\/p>\n<h5><a href=\"https:\/\/www.life-science-alliance.org\/content\/1\/3\/e201800025\"><span style=\"color: #000000;\"><strong>Discovery of a cofactor-independent inhibitor of\u00a0<em>Mycobacterium tuberculosis<\/em>\u00a0InhA<\/strong><\/span><\/a><\/h5>\n<h6><span style=\"color: #800000;\">Xia Y, <strong>Zhou Y<\/strong>, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O&#8217;Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, <strong>Sacchettini J<\/strong>, Tonge PJ, Lenaerts AJ, Parish T, Alley M.\u00a0<\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Life Sci Alliance<\/strong>.<\/em> 2018 Jun 1;1(3): PMID: 30456352<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInRight\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/AJRCCM_cb8aa7cb05599c43da844b5b975eb986-e1573490244152.png\" width=\"200\" height=\"150\" alt=\"AJRCCM\" title=\"AJRCCM\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>6.<\/h2><p><\/p>\n<h5><strong><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30428263\">Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research.\u00a0<\/a><\/span><\/strong><\/h5>\n<h6><span style=\"color: #800000;\">Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, <strong>Sacchettini\u00a0JC<\/strong>, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM.\u00a0<\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Am J Respir Crit Care Med<\/strong>.<\/em> 2018 Nov 14. PMID: 30428263<\/span><\/h6>\n<p><\/p><\/div><\/div><div class=\"timeline_event rda_fadeInLeft\"><div class=\"event_img\"><img decoding=\"async\" class=\"\" src=\"https:\/\/saclab.biobio.tamu.edu\/wp-content\/uploads\/2019\/11\/CellLogo_reasonably_small_400x400-250x250.jpg\" width=\"250\" height=\"250\" alt=\"Cell\" title=\"Cell\" loading=\"lazy\" \/><\/div><div class=\"event_triangle\"><\/div><div class=\"event_info\"><h2>7.<\/h2><p><\/p>\n<h5><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28669536\"><span style=\"color: #000000;\">Development of a Novel Lead that Targets M.\u00a0tuberculosis Polyketide Synthase 13.<\/span><\/a><\/strong><\/h5>\n<h6><span style=\"color: #800000;\"><strong>Aggarwal A<\/strong>, <strong>Parai MK<\/strong>, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, <strong>Snavely T<\/strong>, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, B\u00f6ttger EC, Karakousis PC, Lenaerts AJ, <strong>Sacchettini JC.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #800000;\"><em><strong>Cell<\/strong><\/em>. 2017 Jul 13;170(2):249-259.\u00a0PMCID: 28669536 PMC5509550<\/span><\/h6>\n<p><\/p><\/div><\/div><\/div>\r\n\r\n<!-- Timeline Event END-->\n[\/vc_tab][\/vc_tabs][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column] OUR PUBLICATIONS For all publications, continue to PubMed page. 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