CENTRAL CARBON AND
AMINO ACIDS AND
IDENTIFY TARGET-INHIBITOR PAIRS
USE STRUCTURE-BASED DESIGN AND MEDICINAL CHEMISTRY TO DEVELOP POTENT AND SAFE LEAD MOLECULES
TEST AGAINST WHOLE CELLS TO ENSURE
CHARACTERIZE INHIBITOR BIOCHEMICALLY
SEARCHING FOR INHIBITORS :
SCREENING AND STRUCTURE-BASED DESIGN
MAKING DRUGS :
TEST LEAD MOLECULES FOR EFFICACY
OBTAIN PHARMACOLOGICAL PROFILES
ON LEAD MOLECULES
DEVELOP ANIMAL MODELS OF DISEASE
TESTING DRUGS :
Howdy Siri, what are Lipinski rules?
THE FIELD IN STRUCTURAL BIOLOGY
We leverage structural and biochemical insight along with novel genetic and chemical-genetic tools to study aspects of mycobacterial metabolism that have proven vulnerable to chemical inhibition, search for inhibitors, and develop leads for TB treatment.
In the Sacchettini lab we focus on the identification of small molecules that overcome drug resistance in tumors, particularly of lymphomas and ovarian cancers.
Our lab currently focuses on parasitic diseases such as malaria,
cryptosporidiosis, and two major kinetoplastid diseases – human African trypanosomiasis (sleeping
sickness), and Chagas disease.
RARE GENETIC DISEASES
Studying underlying mechanisms of cell damage in diseases like Menkes and familial ALS allows us to devise novel therapeutic strategies and to develop animal models for testing them.
ILSB Building 1530 301 Old Main Dr, College Station, TX 77843