SACLab | TAMU | saclab.biobio.tamu.edu

IDENTIFY TARGET-INHIBITOR PAIRS

USE STRUCTURE-BASED DESIGN AND MEDICINAL CHEMISTRY TO DEVELOP POTENT AND SAFE LEAD MOLECULES

TEST AGAINST WHOLE CELLS TO ENSURE
TARGETED ACTIVITY

CHARACTERIZE INHIBITOR BIOCHEMICALLY
AND STRUCTURALLY

SEARCHING FOR INHIBITORS :

SCREENING AND STRUCTURE-BASED DESIGN

BOOST THROUGHPUT WITH SAMPLING SPEEDS UP TO ONE SAMPLE PER SECOND, CUTTING TURNAROUND AND STREAMLINING WORKFLOW. HIGH-QUALITY, DATA-RICH SAMPLING WITH CONTACTLESS ACOUSTIC EJECTION - MINIMIZING HANDLING AND CARRYOVER. UNPARALLELED PRECISION AND CONSISTENCY IN COMPLEX SAMPLES, REDUCING RERUNS AND SAVING REAGENTS.

ECHO® MS+ System :

ADVANCED MASS SPECTROMETRY, OPTIMIZED FOR THROUGHPUT

STUDYING

DISEASE-RELATED BIOLOGY

CENTRAL CARBON AND ENERGY METABOLISM

TRANSCRIPTION

TRANSLATION

PROTEIN FOLDING AND DEGRADATION

AMINO ACIDS AND NUCLEOTIDE METABOLISM

CELL WALL

MAKING DRUGS :

MEDICINAL CHEMISTRY

TEST LEAD MOLECULES FOR EFFICACY

OBTAIN PHARMACOLOGICAL PROFILES ON LEAD MOLECULES

DEVELOP ANIMAL MODELS OF DISEASE

TESTING DRUGS :

PHARMACOLOGICAL STUDIES AND ANIMAL MODELS

Howdy Siri, what are Lipinski rules?

LEADING

THE FIELD IN STRUCTURAL BIOLOGY

TUBERCULOSIS

We leverage structural and biochemical insight along with novel genetic and chemical-genetic tools to study aspects of mycobacterial metabolism that have proven vulnerable to chemical inhibition, search for inhibitors, and develop leads for TB treatment.

CANCER

In the Sacchettini lab we focus on the identification of small molecules that overcome drug resistance in tumors, particularly of lymphomas and ovarian cancers.

PARASITIC DISEASES

Our lab currently focuses on parasitic diseases such as malaria, cryptosporidiosis, and two major kinetoplastid diseases – human African trypanosomiasis (sleeping sickness), and Chagas disease.

RARE GENETIC DISEASES

Studying underlying mechanisms of cell damage in diseases like Menkes and familial ALS allows us to devise novel therapeutic strategies and to develop animal models for testing them.