Publications | SACLab | TAMU

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OUR PUBLICATIONS

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Recent Publications

Selected Publications

Dcellpress

1.

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, McNamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC.

5 November 2024

Screenshot 2024-07-25 at 3.21.47 PM

2.

Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions

Henriques-Santos BM, **Baker D, Zhou N, Snavely T, Sacchettini JC*,** Pietrantonio PV.

20 June 2024

3.

Identification of a copper-responsive small molecule inhibitor of uropathogenic Escherichia coli

Hanson BS, Hailemariam A, Yang Y, Mohamed F, Donati GL, Baker D, Sacchettini J*, Cai JJ, Subashchandrabose S.

10 June 2024

https://www.nature.com/ncomms/

4.

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Qu D, Ge P, Botella L, Park SW, Lee HN, Thornton N, Bean JM, Krieger IV, Sacchettini JC*, Ehrt S, Aldrich CC, Schnappinger D.

16 May 2024

ACSPubs-Tagline-CMYK

5.

**Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening**

Inna V. Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A. Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A. Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D. Hupp, Rachael Jetson, Takashi Satoh, John T. S. Yeoman, Ying Zhang, Veronique Dartois, Dirk Schnappinger, Anthony D. Keefe, and James C. Sacchettini

5 April 2024

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6.

**Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase**

Amrita Singh, Samantha Ottavi, Inna Krieger, Kyle Planck, Andrew Perkowski, Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, Dave M Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna Upton, Christopher B Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang , Ben S Gold, Kyu Y Rhee , James C Sacchettini, Nader Fotouhi, Jeffrey Aubé , Carl Nathan

15 March 2024

7.

Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization

Tingfeng Guo, Anthony M. Sperber, Inna V. Krieger, Yi Duan, Veronica R. Chemelewski, James C. Sacchettini, Jennifer K. Herman

4 December 2023

ACSPubs-Tagline-CMYK

8.

Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

Samantha Ottavi, Kelin Li, Jackson G Cacioppo, Andrew J Perkowski, Remya Ramesh, Ben S Gold, Yan Ling, Julia Roberts, Amrita Singh, David Zhang, John Mosior, Laurent Goullieux, Christine Roubert, Eric Bacqué, James C Sacchettini, Carl F Nathan, Jeffrey Aubé

26 June 2023

ACSPubs-Tagline-CMYK

9.

DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery

Siddhant Rath, Saswati Panda, James C. Sacchettini, Steven J. Berthel

22 June 2023

Cell

10.

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

Jidong Zhang, Christine Lair, Christine Roubert, Kwame Amaning, María Belén Barrio, Yannick Benedetti, Zhicheng Cui, Zhongliang Xing, Xiaojun Li, Scott G Franzblau, Nicolas Baurin, Florence Bordon-Pallier, Cathy Cantalloube, Stephanie Sans, Sandra Silve, Isabelle Blanc, Laurent Fraisse, Alexey Rak, Lasse B Jenner, Gulnara Yusupov, Marat Yusupov, Junjie Zhang, Takushi Kaneko, T J Yang, Nader Fotouhi, Eric Nuermberger, Sandeep Tyagi, Fabrice Betoudji, Anna Upton, James C Sacchettini, Sophie Lagrange

2 March 2023

ACSPubs-Tagline-CMYK

11.

1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

Singh V, Grzegorzewicz AE, Fienberg S, Müller R, Khonde LP, Sanz O, Alfonso S, Urones B, Drewes G, Bantscheff M, Ghidelli-Disse S, Ioerger TR, Angala B, Liu J, Lee RE, Sacchettini JC, Krieger IV, Jackson M, Chibale K, Ghorpade SR.

3 November 2022

https://www.nature.com/ncomms/

12.

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

Sachin S Katti, Inna V Krieger, Jihyae Ann, Jeewoo Lee, James C Sacchettini, Tatyana I Igumenova

16 May 2022

https://www.nature.com/ncomms/

13.

CinA mediates multidrug tolerance in Mycobacterium tuberculosis

Kaj M Kreutzfeldt, Robert S Jansen, Travis E Hartman, Alexandre Gouzy, Ruojun Wang, Inna V Krieger, Matthew D Zimmerman, Martin Gengenbacher, Jansy P Sarathy, Min Xie, Véronique Dartois, James C Sacchettini, Kyu Y Rhee, Dirk Schnappinger , Sabine Ehrt

22 April 2022

https://www.nature.com/ncomms/

14.

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis

Cui Z, Li Xiaojun, Shin J, Gamper H, Hou YM, Sacchettini JC, Zhang J.

21 January 2022

ACSPubs-Tagline-CMYK

15.

**In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas**

Ottavi S, Scarry SM, Mosior J, Ling Y, Roberts J, Singh A, Zhang D, Goullieux L, Roubert C, Bacqué E, Lagiakos HR, Vendome J, Moraca F, Li K, Perkowski AJ, Ramesh R, Bowler MM, Tracy W, Feher VA, Sacchettini JC, Gold BS, Nathan CF, Aubé J.

19 January 2022

ACSPubs-Tagline-CMYK

16.

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, Acharya A, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Román EM, Torres-Gómez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D, Sacchettini JC, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG.

13 January 2022

ACSPubs-Tagline-CMYK

17.

Second-Shell Amino Acid R266 Helps Determine N-Succinylamino Acid Racemase Reaction Specificity in Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Enzymes

Dat P Truong, Simon Rousseau, Benjamin W Machala, Jamison P Huddleston, Mingzhao Zhu, Kenneth G Hull, Daniel Romo, Frank M Raushel, James C Sacchettini, Margaret E Glasner

30 November 2021

ACSPubs-Tagline-CMYK

18.

**Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2 R,3 S)-2-Hydroxy-3-(nitromethyl)succinic acid**

Drake M Mellott, Dan Torres, Inna V Krieger, Scott A Cameron, Zahra Moghadamchargari, Arthur Laganowsky, James C Sacchettini, Thomas D Meek, Lawrence D Harris

27 October 2021

nature_logo

19.

Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of Mycobacterium smegmatis

Han Wang, Gloria M Conover, Song-I Han, James C Sacchettini, Arum Han

20 May 2021

https://jb.asm.org/

20.

Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis

Shilpika Pandey, Amrita Singh, Guangli Yang, Felipe B d’Andrea, Xiuju Jiang, Travis E Hartman, John W Mosior, Ronnie Bourland, Ben Gold, Julia Roberts, Annie Geiger, Su Tang, Kyu Rhee, Ouathek Ouerfelli, James C Sacchettini, Carl F Nathan, Kristin Burns-Huang

22 September 2021

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21.

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Bree B. Aldridge, David Barros-Aguirre, Clifton E. Barry III, Robert H. Bates, Steven J. Berthel, Helena I. Boshoff, Kelly Chibale, Xin-Jie Chu, Christopher B. Cooper, Véronique Dartois, Ken Duncan, Nader Fotouhi, Fabian Gusovsky, Philip A. Hipskind, Dale J. Kempf, Joël Lelièvre, Anne J. Lenaerts, Case W. McNamara, Valerie Mizrahi, Carl Nathan, David B. Olsen, Tanya Parish, H. Michael Petrassi, Alexander Pym, Kyu Y. Rhee, Gregory T. Robertson, Jeremy Michael Rock, Eric J. Rubin, Betsy Russell, David G.Russell, James C. Sacchettini, Dirk Schnappinger, Michael Schrimpf, Anna M. Upton, Peter Warner, Paul Graham Wyatt & Ying Yuan

05 July 2021

97edd8de-c784-4fe2-837d-216cc5b75aaa.png.200x200_q95_detail_letterbox_upscale

22.

Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis

Katherine A Black, Lijun Duan, Lungelo Mandyoli, Bruna P Selbach, Weizhen Xu, Sabine Ehrt, James C Sacchettini, Kyu Y Rhee

05 May 2021

ACSPubs-Tagline-CMYK

23.

**Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid**

Truc Viet Pham, Drake M Mellott, Zahra Moghadamchargari, Kevin Chen, Inna Krieger, Arthur Laganowsky, James C Sacchettini, Thomas D Meek

10 Mar 2021

https://www.nature.com/ncomms/

24.

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Jared S Mackenzie, Dirk A Lamprecht, Rukaya Asmal, John H Adamson, Khushboo Borah, Dany J V Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C Sacchettini, Joel N Glasgow, Adrie J C Steyn

30 Nov 2020

25.

A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

Danish Khan, Dongju Lee, Gulcin Gulten , Anup Aggarwal , Joshua Wofford, Inna Krieger, Ashutosh Tripathi , John W Patrick, Debra M Eckert, Arthur Laganowsky , James C. Sacchettini , Paul Lindahl, Vytas A Bankaitis

11 Aug 2020

26.

The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition

Inna Krieger, Vladimir Kuznetsov, Jeng-Yih Chang, Junjie Zhang, Samir Moussa, Ryland Young, James C Sacchettini

17 June 2020

27.

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

Liam M. Guthrie, Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas C. Snavely, Hannah Faith Greene, Elyssa Nunez, Brogan Lynch, Courtney De Ville, Vinit Shanbhag, Franklin R. Lopez, Arjun Acharya, Michael J. Petris, Byung-Eun Kim, Vishal M. Gohil, James C. Sacchettini

8 May 2020

https://www.nature.com/ncomms/

28.

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Robert S. Jansen, Lungelo Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna Selbach, Kristine M. Guinn, Eric J. Rubin, James C. Sacchettini & Kyu Y. Rhee

23 April 2020

https://onlinelibrary.wiley.com/

29.

Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.

John Mosior, Ronnie Bourland, Shivatheja Soma, Carl Nathan, James C. Sacchettini

29 March 2020

https://www.nature.com/ja/

30.

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening.

Junichi Taira, Tomohiro Umei, Keitaro Inoue, Mitsuru Kitamura, Francois Berenger, James C. Sacchettini, Hiroshi Sakamoto & Shunsuke Aoki

9 March 2020

https://www.nature.com/ncomms/

31.

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Qingan Sun, Xiaojun Li, Lisa M. Perez, Wanliang Shi, Ying Zhang, and James C. Sacchettini

17 January 2020

1.

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

Liam M. Guthrie, Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas C. Snavely, Hannah Faith Greene, Elyssa Nunez, Brogan Lynch, Courtney De Ville, Vinit Shanbhag, Franklin R. Lopez, Arjun Acharya, Michael J. Petris, Byung-Eun Kim, Vishal M. Gohil, James C. Sacchettini

Science. 2020 May 8;368(6491). PMID: 32381719

https://www.nature.com/ncomms/

2.

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Qingan Sun, Xiaojun Li, Lisa M. Perez, Wanliang Shi, Ying Zhang, and James C. Sacchettini

Nature Communications. 2020 Jan 17; 339; PMID: 31953389

3.

**Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition**

Elaine Ballinger, John Mosior, Travis Hartman, Kristin Burns-Huang, Ben Gold, Roxanne Morris, Laurent Goullieux, Isabelle Blanc, Julien Vaubourgeix, Sophie Lagrange, Laurent Fraisse, Stéphanie Sans, Cedric Couturier, Eric Bacqué, Kyu Rhee, Sarah M. Scarry, Jeffrey Aubé, Guangbin Yang, Ouathek Ouerfelli, Dirk Schnappinger, Thomas R. Ioerger, Curtis A. Engelhart, Jennifer A. McConnell, Kathrine McAulay, Allison Fay, Christine Roubert, James Sacchettini, Carl Nathan

Science. 2019 Feb 1;363(6426). PMID: 30705156

4.

Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.

Miller BK, Hughes R, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, Sacchettini JC, Braunstein M.

Elife. 2019 Jan 3;8. PMID: 30604681

Life-Sci-Alliance

5.

**Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA**

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O’Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M.

Life Sci Alliance. 2018 Jun 1;1(3): PMID: 30456352

AJRCCM

6.

Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research.

Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM.

Am J Respir Crit Care Med. 2018 Nov 14. PMID: 30428263

Cell

7.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259. PMCID: 28669536 PMC5509550