STUDYING
DISEASE-RELATED
BIOLOGY
CENTRAL CARBON AND
ENERGY METABOLISM
TRANSCRIPTION
TRANSLATION
PROTEIN FOLDING
AND DEGRADATION
AMINO ACIDS AND
NUCLEOTIDE
METABOLISM
CELL WALL
IDENTIFY TARGET-INHIBITOR PAIRS
USE STRUCTURE-BASED DESIGN AND MEDICINAL CHEMISTRY TO DEVELOP POTENT AND SAFE LEAD MOLECULES
TEST AGAINST WHOLE CELLS TO ENSURE
TARGETED ACTIVITY
CHARACTERIZE INHIBITOR BIOCHEMICALLY
AND STRUCTURALLY
SEARCHING FOR INHIBITORS :
SCREENING AND STRUCTURE-BASED DESIGN
MAKING DRUGS :
MEDICINAL CHEMISTRY
TEST LEAD MOLECULES FOR EFFICACY
OBTAIN PHARMACOLOGICAL PROFILES
ON LEAD MOLECULES
DEVELOP ANIMAL MODELS OF DISEASE
TESTING DRUGS :
PHARMACOLOGICAL STUDIES
AND
ANIMAL MODELS
Howdy Siri, what are Lipinski rules?
LEADING
THE FIELD IN STRUCTURAL BIOLOGY
TUBERCULOSIS
We leverage structural and biochemical insight along with novel genetic and chemical-genetic tools to study aspects of mycobacterial metabolism that have proven vulnerable to chemical inhibition, search for inhibitors, and develop leads for TB treatment.
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CANCER
In the Sacchettini lab we focus on the identification of small molecules that overcome drug resistance in tumors, particularly of lymphomas and ovarian cancers.
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PARASITIC DISEASES
Our lab currently focuses on parasitic diseases such as malaria,
cryptosporidiosis, and two major kinetoplastid diseases – human African trypanosomiasis (sleeping
sickness), and Chagas disease.
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RARE GENETIC DISEASES
Studying underlying mechanisms of cell damage in diseases like Menkes and familial ALS allows us to devise novel therapeutic strategies and to develop animal models for testing them.
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